Ser591
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Home > Phosphorylation Site Page: > Ser591  -  GAB2 (mouse)

Site Information
PVPSGTNsPAPKKST   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 62877800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , MCF10A1 (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 )
Kinases, in vitro:
ERK1 (human) ( 1 )
Treatments:
EGF ( 1 ) , PD184352 ( 1 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on GAB2:
molecular association, regulation ( 1 )
Inhibit interaction with:
PIK3R1 (human) ( 1 )

References 

1

Zhang X, et al. (2017) Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling. Mol Cell Biol 37
28096188   Curated Info

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