Tyr109

Site Information
tPtPPGQyFyPRGGG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 473669
Associated spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	cervical cancer ( 1 ) , cervical adenocarcinoma ( 1 ) , gastric cancer ( 2 ) , gastric carcinoma ( 2 ) , lymphoma ( 3 , 4 ) , Hodgkin's lymphoma ( 3 , 4 )
Relevant cell line - cell type - tissue:	HeLa S3 (cervical) ( 1 ) , L540 (lymphoid) ( 3 , 4 ) , MKN-45 (gastric) ( 2 )

References
1	Yamaguchi N, et al. (2015) c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21. Biochem J 471, 67-77 26217035 Curated Info
2	Mulhern D (2011) CST Curation Set: 12647; Year: 2011; Biosample/Treatment: cell line, MKN-45/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Antibodies Used to Purify Peptides prior to LCMS: TPP Motif (TPP) (D61C3) Rabbit mAb Cat#: 5757, PTMScan(R) TPP Motif (TPP) Immunoaffinity Beads Cat#: 5758 Curated Info
3	Gu TL, et al. (2010) Identification of activated Tnk1 kinase in Hodgkin's lymphoma. Leukemia 24, 861-5 20090780 Curated Info
4	Gu T (2006) CST Curation Set: 1936; Year: 2006; Biosample/Treatment: cell line, L540/untreated; Disease: Hodgkin's lymphoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info