Ser2624
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Home > Phosphorylation Site Page: > Ser2624  -  DNAPK (human)

Site Information
QtRtQEGsLsARWPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 473575

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 ) , mutation of modification site ( 4 ) , phospho-antibody ( 7 )
Disease tissue studied:
breast cancer ( 3 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 7 ) , A498 (renal) ( 6 ) , breast ( 2 , 3 ) , HeLa_Meta (cervical) ( 5 ) , HeLa_Pro (cervical) ( 5 ) , HeLa_Telo (cervical) ( 5 ) , ovary ( 4 ) , Vero E6-S ('epithelial, kidney') ( 1 )

Upstream Regulation
Treatments:
ionizing_radiation ( 7 ) , MG132 ( 5 ) , MG132_withdrawal ( 5 )

Downstream Regulation
Effects of modification on DNAPK:
molecular association, regulation ( 4 ) , protein conformation ( 4 )
Effects of modification on biological processes:
DNA repair, induced ( 4 )
Inhibit interaction with:
DNA ( 4 )

References 

1

Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell 182
32645325   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Neal JA, et al. (2014) Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation. Mol Cell Biol 34, 2162-2175
24687855   Curated Info

5

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info

6

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

7

Douglas P, et al. (2007) The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Mol Cell Biol 27, 1581-91
17158925   Curated Info

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