Thr3950
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Home > Phosphorylation Site Page: > Thr3950  -  DNAPK (human)

Site Information
GHAFGSAtQFLPVPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 473573

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , BT (epithelial) ( 2 ) , HeLa (cervical) ( 1 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
DNAPK (human) ( 1 )
Kinases, in vitro:
DNAPK (human) ( 2 )
Treatments:
camptothecin ( 2 ) , etoposide ( 2 ) , ionizing_radiation ( 2 ) , nocodazole ( 1 ) , NU7441 ( 1 ) , okadaic_acid ( 2 ) , thymidine ( 1 )

Downstream Regulation
Effects of modification on DNAPK:
enzymatic activity, inhibited ( 2 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Douglas P, et al. (2014) Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Biosci Rep 34
24844881   Curated Info

2

Douglas P, et al. (2007) The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Mol Cell Biol 27, 1581-91
17158925   Curated Info

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