Tyr299

Site Information
KLNSIGNyykPWFFK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 473187

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	leukemia ( 2 ) , acute lymphocytic leukemia ( 2 )
Relevant cell line - cell type - tissue:	CHO (fibroblast) ( 1 ) , SEM (B lymphocyte) ( 2 )

Downstream Regulation
Effects of modification on Diminuto:	enzymatic activity, induced ( 1 ) , protein stabilization ( 1 )

References
1	Luu W, et al. (2014) Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis. J Lipid Res 55, 410-20 24363437 Curated Info
2	Moritz A (2006) CST Curation Set: 1832; Year: 2006; Biosample/Treatment: cell line, SEM/-; Disease: acute lymphocytic leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info

References

Luu W, et al. (2014) Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis. J Lipid Res 55, 410-20
24363437 Curated Info

Moritz A (2006) CST Curation Set: 1832; Year: 2006; Biosample/Treatment: cell line, SEM/-; Disease: acute lymphocytic leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info