Ser314
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Home > Phosphorylation Site Page: > Ser314  -  5-HT(2A) (rat)

Site Information
AGRRTMQsISNEQKA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6057801

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
fibroblast-embryo ( 1 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
RSK2 (human) ( 1 )
Kinases, in vitro:
RSK2 (human) ( 1 )
Treatments:
EGF ( 1 ) , SL0101 ( 1 )

Downstream Regulation
Effects of modification on 5-HT(2A):
activity, inhibited ( 1 ) , receptor desensitization, altered ( 1 )

References 

1

Strachan RT, et al. (2009) Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling. J Biol Chem 284, 5557-73
19103592   Curated Info