Tyr259

Site Information
sFCGtVEyMAPEVVN SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 472958

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:	'fat, brown' ( 4 ) , embryo ( 2 ) , heart ( 4 ) , liver ( 1 , 4 ) , lung ( 4 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 3 ) , pancreas ( 4 ) , spleen ( 4 ) , testis ( 4 )

References
1	Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83 23140645 Curated Info
2	Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201 22322096 Curated Info
3	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
4	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info