Lys24
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Home > Ubiquitylation Site Page: > Lys24  -  p53 (human)

Site Information
EtFsDLWkLLPENNV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 60176101

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) ( 1 ) , U2OS (bone cell) ( 1 )

Downstream Regulation
Effects of modification on p53:
intracellular localization ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , cell growth, inhibited ( 1 )
Induce interaction with:
BAK1 (human) ( 1 )
Inhibit interaction with:
MCL1 (human) ( 1 )

References 

1

Zhang X, et al. (2016) TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Mol Cell 64, 803-814
27818144   Curated Info