Ser154
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Home > Phosphorylation Site Page: > Ser154  -  SIRT1 (mouse)

Site Information
NGFHsCEsDDDDRTS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6006902

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
293T (epithelial) ( 3 ) , endothelial-aorta ( 1 ) , myocyte-heart ( 1 ) , testis ( 2 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 3 )
Kinases, in vitro:
CK2A1 (human) ( 3 )
Treatments:
development ( 1 ) , ionizing_radiation ( 3 ) , mutation ( 1 ) , TBCA ( 3 )

Downstream Regulation
Effects of modification on SIRT1:
enzymatic activity, induced ( 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 3 ) , transcription, induced ( 1 )

References 

1

Kong D, et al. (2016) SIRT1-mediated ERĪ² suppression in the endothelium contributes to vascular aging. Aging Cell
27470296   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

3

Kang H, Jung JW, Kim MK, Chung JH (2009) CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One 4, e6611
19680552   Curated Info