Lys619
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Home > Acetylation Site Page: > Lys619  -  AR (human)

Site Information
CPSCRLRkCYEAGMT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 59149200

In vivo Characterization
Methods used to characterize site in vivo:
modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
prostate cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on AR:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 ) , POLR2A (human) ( 1 )
Inhibit interaction with:
HSP90A (human) ( 1 )

References 

1

DePaolo JS, et al. (2016) Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis. Oncotarget 7, 71417-71428
27659526   Curated Info