Thr528
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Home > Phosphorylation Site Page: > Thr528  -  HIF2A (human)

Site Information
FNELDLEtLAPYIPM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 59087902

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 2 )
Disease tissue studied:
liver cancer ( 2 ) , hepatocellular carcinoma ( 2 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 ) , HepG2 (hepatic) ( 2 ) , Huh7 (hepatic) ( 2 )

Upstream Regulation
Kinases, in vitro:
CK1D (human) ( 2 )

Downstream Regulation
Effects of modification on HIF2A:
intracellular localization ( 2 )
Effects of modification on biological processes:
transcription, induced ( 2 )

References 

1

Daly LA, et al. (2021) Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α. Sci Signal 14
34285132   Curated Info

2

Pangou E, et al. (2016) HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia. J Cell Sci 129, 4213-4226
27686097   Curated Info

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