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Site Information |
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FELRkTQtsMSLGTt SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 5891858 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
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Downstream Regulation | |
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Effects of modification on MLKL: | |
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Relevant diseases: |
References | |
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Chen X, et al. (2022) Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death. Nat Cell Biol
35256774 Curated Info |
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Zu R, et al. (2021) Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production. Cell Death Dis 12, 994
34689152 Curated Info |
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Caccamo A, et al. (2017) Necroptosis activation in Alzheimer's disease. Nat Neurosci 20, 1236-1246
28758999 Curated Info |
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Yoon S, Bogdanov K, Kovalenko A, Wallach D (2016) Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ 23, 253-60
26184911 Curated Info |
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Ofengeim D, et al. (2015) Activation of necroptosis in multiple sclerosis. Cell Rep 10, 1836-49
25801023 Curated Info |
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Wang H, et al. (2014) Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3. Mol Cell 54, 133-46
24703947 Curated Info |
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Sun L, et al. (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-27
22265413 Curated Info |
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Moritz A (2007) CST Curation Set: 2970; Year: 2007; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info |