Tyr436
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Home > Phosphorylation Site Page: > Tyr436  -  AMPKA2 (human)

Site Information
EWKVVNAyHLRVRRK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 58109404

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Fyn (human) ( 1 )
Kinases, in vitro:
Fyn (human) ( 1 )

Downstream Regulation
Effects of modification on AMPKA2:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
autophagy, inhibited ( 1 )

References 

1

Yamada E, et al. (2016) Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy. Oncotarget 7, 74612-74629
27626315   Curated Info