Ser269
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Home > Phosphorylation Site Page: > Ser269  -  PFKFB3 (human)

Site Information
QGRIGGDsGLSsRGK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 58109402

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
IKKB (human) ( 1 )
Kinases, in vitro:
IKKB (human) ( 1 )

Downstream Regulation
Effects of modification on PFKFB3:
enzymatic activity, inhibited ( 1 ) , protein degradation ( 1 )

References 

1

Reid MA, et al. (2016) IKK╬▓ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev 30, 1837-51
27585591   Curated Info