Ser46
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Home > Phosphorylation Site Page: > Ser46  -  eIF3-epsilon (human)

Site Information
PAAAPASsSDPAAAA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448818

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CDK11B (human) ( 2 ) , CDK19 (human) ( 1 )
Kinases, in vitro:
CDK11B (human) ( 2 ) , CDK19 (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 2 )

References 

1

Shi J, Hershey JW, Nelson MA (2009) Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. FEBS Lett 583, 971-7
19245811   Curated Info

2

Shi J, et al. (2003) The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis. J Biol Chem 278, 5062-71
12446680   Curated Info