Ser394
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Home > Phosphorylation Site Page: > Ser394  -  p70S6K (mouse)

Site Information
TRQtPVDsPDDSTLS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448806

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 4 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 2 ) , breast [PDK1 (mouse), homozygous knockout] ( 1 ) , MEF (fibroblast) ( 3 ) , T lymphocyte ( 4 )

Upstream Regulation
Regulatory protein:
AMPKA1 (mouse) ( 3 ) , FOXO1A (human) ( 3 ) , FOXO1A (mouse) ( 3 ) , FOXO3A (human) ( 3 ) , FOXO3A (mouse) ( 3 ) , PDK1 (human) ( 1 ) , RICTOR (mouse) ( 3 ) , SESN3 (human) ( 3 ) , STAT4 (mouse) ( 4 )
Treatments:
4-HT ( 3 ) , acadesine ( 2 ) , antigenic stimulation ( 4 ) , B7 ( 4 ) , glucose ( 3 ) , H2O2 ( 3 ) , IL-12 ( 4 ) , insulin ( 4 ) , LY294002 ( 4 ) , rapamycin ( 4 ) , serum ( 3 )

References 

1

Du J, et al. (2016) PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model. Oncogene 35, 3314-23
26455327   Curated Info

2

Williams T, et al. (2011) AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress. Proc Natl Acad Sci U S A 108, 5849-54
21436046   Curated Info

3

Chen CC, et al. (2010) FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell 18, 592-604
20412774   Curated Info

4

Rao RR, Li Q, Odunsi K, Shrikant PA (2010) The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 32, 67-78
20060330   Curated Info