Thr138
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Home > Phosphorylation Site Page: > Thr138  -  CDK5R1 (rat)

Site Information
PAITSAGtPKRVIVQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471393

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 3 ) , [32P] bio-synthetic labeling ( 3 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 1 ) , 'neuron, cortical'-brain ( 2 , 3 ) , 293 (epithelial) ( 3 ) , COS (fibroblast) ( 2 ) , HEK293T (epithelial) ( 1 ) , PC-12 (chromaffin) ( 1 )

Upstream Regulation
Regulatory protein:
NGFR (rat) ( 1 ) , PTPN13 (human) ( 1 )
Putative in vivo kinases:
CDK5 (human) ( 2 )
Treatments:
GTP ( 1 ) , intracerebral hemorrhage ( 1 ) , okadaic_acid ( 3 ) , thrombin ( 1 )

Downstream Regulation
Effects of modification on CDK5R1:
protein stabilization ( 1 , 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , signaling pathway regulation ( 1 )

References 

1

Zhou T, et al. (2019) The p35/CDK5 signaling is regulated by p75NTR in neuronal apoptosis after intracerebral hemorrhage. J Cell Physiol
30770557   Curated Info

2

Hosokawa T, et al. (2010) Quantitative measurement of in vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE. Mol Cell Proteomics 9, 1133-43
20097924   Curated Info

3

Kamei H, et al. (2007) Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. J Biol Chem 282, 1687-94
17121855   Curated Info