Thr117
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Home > Phosphorylation Site Page: > Thr117  -  TRAF2 (mouse)

Site Information
DGCTWKGtLKEYESC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471341

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
TNF-R1 (mouse) ( 1 ) , TNF-R2 (human) ( 1 )
Putative in vivo kinases:
PKCE (mouse) ( 1 ) , PKCZ (mouse) ( 1 )
Kinases, in vitro:
PKCE (mouse) ( 1 ) , PKCZ (mouse) ( 1 )
Treatments:
chelerythrine ( 1 ) , siRNA ( 1 ) , TNF ( 1 )

Downstream Regulation
Effects of modification on TRAF2:
molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
IKKA (human) ( 1 ) , IKKB (human) ( 1 )

References 

1

Li S, Wang L, Dorf ME (2009) PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol Cell 33, 30-42
19150425   Curated Info