Ser16

Site Information
AGGsGsEsPLLKGRR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 471220

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 )
Relevant cell line - cell type - tissue:	'3T3-L1, differentiated' (adipocyte) ( 2 , 3 , 5 ) , 'brain, cerebellum' ( 14 ) , 'brain, cerebral cortex' ( 13 , 14 ) , 'brain, hippocampus, dentate gyrus' ( 14 ) , 'brain, midbrain' ( 14 ) , 'fat, brown' ( 11 ) , brain ( 9 , 10 , 11 , 12 ) , heart ( 6 ) , kidney ( 11 ) , liver ( 8 ) , liver [leptin (mouse), homozygous knockout] ( 8 ) , lung ( 11 ) , macrophage-peritoneum ( 7 ) , pancreas ( 11 ) , RAW 264.7 (macrophage) ( 4 ) , spleen ( 11 ) , testis ( 11 )

In vivo Characterization

Methods used to characterize site in vivo:

mass spectrometry ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 )

Relevant cell line - cell type - tissue:

'3T3-L1, differentiated' (adipocyte) ( 2 , 3 , 5 ) , 'brain, cerebellum' ( 14 ) , 'brain, cerebral cortex' ( 13 , 14 ) , 'brain, hippocampus, dentate gyrus' ( 14 ) , 'brain, midbrain' ( 14 ) , 'fat, brown' ( 11 ) , brain ( 9 , 10 , 11 , 12 ) , heart ( 6 ) , kidney ( 11 ) , liver ( 8 ) , liver [leptin (mouse), homozygous knockout] ( 8 ) , lung ( 11 ) , macrophage-peritoneum ( 7 ) , pancreas ( 11 ) , RAW 264.7 (macrophage) ( 4 ) , spleen ( 11 ) , testis ( 11 )

References
1	Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250 27841257 Curated Info
2	Minard AY, et al. (2016) mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Cell Rep 17, 29-36 27681418 Curated Info
3	Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6 26060331 Curated Info
4	Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44 25367039 Curated Info
5	Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20 23684622 Curated Info
6	Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11 23737553 Curated Info
7	Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51 22942356 Curated Info
8	Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83 23140645 Curated Info
9	Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29 22645316 Curated Info
10	Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9 22807455 Curated Info
11	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
12	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
13	Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82 19737024 Curated Info
14	Trinidad JC, et al. (2008) Quantitative analysis of synaptic phosphorylation and protein expression. Mol Cell Proteomics 7, 684-96 18056256 Curated Info