Arg2253
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Home > Di-methylation Site Page: > Arg2253  -  Notch 1 (mouse)

Site Information
AALAGGSrLAFEPPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56852000

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , Beko (T lymphocyte) ( 1 ) , MEF (fibroblast) ( 1 ) , PANC-1 (pancreatic) ( 1 ) , SKRC-17 (renal) ( 1 )

Downstream Regulation
Effects of modification on Notch 1:
activity, induced ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Hein K, et al. (2015) Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response. Sci Signal 8, ra30
25805888   Curated Info