Ser293
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Home > Phosphorylation Site Page: > Ser293  -  nNOS (rat)

Site Information
QSPTKNGsPSRCPRF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56689901

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , microscopy-colocalization with upstream kinase ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
Alzheimer's disease ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 1 ) , BAEC (endothelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (rat) ( 1 )
Kinases, in vitro:
CDK5 (human) ( 1 )

Downstream Regulation
Effects of modification on nNOS:
protein conformation ( 1 )

References 

1

Kwon KJ, et al. (2016) Disruption of neuronal nitric oxide synthase dimerization contributes to the development of Alzheimer's disease: Involvement of cyclin-dependent kinase 5-mediated phosphorylation of neuronal nitric oxide synthase at Ser(293). Neurochem Int 99, 52-61
27296112   Curated Info