Ser412

Site Information
DPCPMLEsPGAPCRS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 56668621

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 )
Disease tissue studied:	HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , breast ( 2 ) , HeLa (cervical) ( 1 ) , NCI-H1299 (pulmonary) ( 1 ) , PC9 (pulmonary) ( 1 )

Downstream Regulation
Effects of modification on HDAC6:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	cell motility, induced ( 1 )
Induce interaction with:	PIN1 (human) ( 1 )

References
1	Chuang HH, et al. (2018) Pin1 Is Involved in HDAC6-mediated Cancer Cell Motility. Int J Med Sci 15, 1573-1581 30443180 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info