Thr324
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Home > Phosphorylation Site Page: > Thr324  -  HIF2A (human)

Site Information
VWLETQGtVIYNPRN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471073

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:
U2OS (bone cell) ( 1 )

Upstream Regulation
Kinases, in vitro:
PDK1 (human) ( 1 )

Downstream Regulation
Effects of modification on HIF2A:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , transcription, altered ( 1 )
Inhibit interaction with:
SP1 (human) ( 1 )

References 

1

To KK, et al. (2006) The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J 25, 4784-94
17024177   Curated Info

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