Ser95
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Home > Phosphorylation Site Page: > Ser95  -  Nur77 (human)

Site Information
TSSSSATsPASASFk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471072

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 )
Disease tissue studied:
gastric cancer ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 , 2 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 2 )
Kinases, in vitro:
JNK1 (human) ( 2 )
Treatments:
anisomycin ( 2 ) , CIAP ( 2 ) , EGF ( 1 ) , JNK_inhibitor_I ( 2 ) , okadaic_acid ( 2 ) , PD98059 ( 2 ) , SB203580 ( 2 ) , SP600125 ( 1 )

Downstream Regulation
Effects of modification on Nur77:
activity, inhibited ( 2 ) , molecular association, regulation ( 1 ) , protein degradation ( 2 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , transcription, altered ( 2 )
Induce interaction with:
PIN1 (human) ( 1 )
Inhibit interaction with:
DNA ( 2 )

References 

1

Chen HZ, et al. (2012) Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene 31, 2876-87
22002310   Curated Info

2

Liu B, et al. (2007) Regulation of the orphan receptor TR3 nuclear functions by c-Jun N terminal kinase phosphorylation. Endocrinology 148, 34-44
17023523   Curated Info

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