Thr410
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Home > Phosphorylation Site Page: > Thr410  -  PKCZ (mouse)

Site Information
GPGDTTstFCGTPNY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447510

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , mutation of modification site ( 6 ) , phospho-antibody ( 4 , 5 , 6 , 7 ) , western blotting ( 4 , 5 , 6 )
Disease tissue studied:
cervical cancer ( 4 ) , cervical adenocarcinoma ( 4 ) , lung cancer ( 4 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 3 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 7 ) , A549 (pulmonary) ( 4 ) , aorta ( 4 ) , BAEC (endothelial) ( 4 ) , chondrocyte ( 6 ) , HeLa S3 (cervical) ( 4 ) , HUVEC (endothelial) ( 4 ) , keratinocyte-skin ( 5 )

Upstream Regulation
Regulatory protein:
CDC42 iso1 (mouse) ( 5 ) , eNOS (mouse) ( 4 )
Treatments:
linoleic_acid ( 7 ) , simvastatin ( 4 ) , SNP ( 6 )

References 

1

Mayanglambam A, Bhavanasi D, Vijayan KV, Kunapuli SP (2011) Differential dephosphorylation of the protein kinase C-zeta (PKCζ) in an integrin αIIbβ3-dependent manner in platelets. Biochem Pharmacol 82, 505-13
21645497   Curated Info

2

Hatziapostolou M, et al. (2011) Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration. Sci Signal 4, ra55
21868363   Curated Info

3

Tucker M (2009) CST Curation Set: 8604; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

4

Choi HC, et al. (2008) Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. J Biol Chem 283, 20186-97
18474592   Curated Info

5

Wu X, et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20, 571-85
16510873   Curated Info

6

Kim JS, et al. (2005) p38 kinase mediates nitric oxide-induced apoptosis of chondrocytes through the inhibition of protein kinase C zeta by blocking autophosphorylation. Cell Death Differ 12, 201-12
15665819   Curated Info

7

Gao Z, et al. (2004) Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol 18, 2024-34
15143153   Curated Info