Ser77
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Home > Phosphorylation Site Page: > Ser77  -  RPL13A (human)

Site Information
PYHFrAPsRIFWRTV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 5594501

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 4 ) , immunoprecipitation ( 2 , 3 , 4 ) , mass spectrometry ( 4 , 5 ) , mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 2 ) , western blotting ( 2 , 3 , 4 )
Disease tissue studied:
lymphoma ( 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
BTI-Tn-5B1-4 ( 4 ) , Jurkat (T lymphocyte) ( 5 ) , RAW 264.7 (macrophage) ( 2 ) , U-937 (myeloid) ( 2 , 3 , 4 )

Upstream Regulation
Putative in vivo kinases:
DAPK1 (human) ( 2 ) , DAPK3 (human) ( 2 , 3 , 4 )
Kinases, in vitro:
DAPK3 (human) ( 4 )
Treatments:
cycloheximide ( 3 ) , IFN-gamma ( 2 , 3 , 4 ) , KN-62 ( 4 ) , LDL_oxidized ( 3 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on RPL13A:
activity, induced ( 4 ) , molecular association, regulation ( 3 ) , protein degradation ( 3 ) , ubiquitination ( 3 )
Effects of modification on biological processes:
translation, altered ( 4 ) , translation, inhibited ( 3 )
Induce interaction with:
GAPDH (human) ( 3 )

References 

1

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

2

Arif A, Chatterjee P, Moodt RA, Fox PL (2012) Heterotrimeric GAIT Complex Drives Transcript-Selective Translation Inhibition in Murine Macrophages. Mol Cell Biol 32, 5046-55
23071094   Curated Info

3

Jia J, et al. (2012) Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation. Mol Cell 47, 656-63
22771119   Curated Info

4

Mukhopadhyay R, et al. (2008) DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Mol Cell 32, 371-82
18995835   Curated Info

5

Possemato A (2008) CST Curation Set: 3770; Year: 2008; Biosample/Treatment: cell line, Jurkat/pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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