Ser322
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Home > Phosphorylation Site Page: > Ser322  -  TACSTD2 (human)

Site Information
GELRkEPsL______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 470219

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , flow cytometry ( 3 ) , immunoassay ( 1 ) , mass spectrometry ( 4 , 5 , 6 , 7 , 8 , 10 , 11 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
breast cancer ( 1 , 6 , 10 ) , HER2 positive breast cancer ( 4 ) , luminal A breast cancer ( 4 ) , luminal B breast cancer ( 4 ) , breast cancer, triple negative ( 4 , 6 ) , colorectal cancer ( 1 , 3 ) , colorectal carcinoma ( 1 , 3 ) , lung cancer ( 8 , 10 ) , non-small cell lung cancer ( 10 ) , non-small cell lung adenocarcinoma ( 8 ) , ovarian cancer ( 6 ) , pancreatic cancer ( 3 ) , pancreatic carcinoma ( 3 ) , pancreatic ductal adenocarcinoma ( 7 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 7 ) , breast ( 4 , 6 ) , BT-20 (breast cell) ( 10 ) , BT-549 (breast cell) ( 10 ) , Calu 6 (pulmonary) ( 10 ) , DU 145 (prostate cell) ( 1 ) , H2009 (pulmonary) ( 10 ) , H2077 (pulmonary) ( 10 ) , H2887 (pulmonary) ( 10 ) , H322M (pulmonary) ( 10 ) , HCC1359 (pulmonary) ( 10 ) , HCC1937 (breast cell) ( 10 ) , HCC2279 (pulmonary) ( 10 ) , HCC366 (pulmonary) ( 10 ) , HCC4006 (pulmonary) ( 10 ) , HCC78 (pulmonary) ( 10 ) , HCC827 (pulmonary) ( 10 ) , HCT116 (intestinal) ( 1 , 3 ) , HeLa (cervical) ( 5 , 11 ) , HOP62 (pulmonary) ( 10 ) , LCLC-103H (pulmonary) ( 10 ) , lung ( 8 ) , MCF-7 (breast cell) ( 1 , 10 ) , MDA-MB-231 (breast cell) ( 10 ) , MDA-MB-468 (breast cell) ( 10 ) , MTE4-14 ( 2 ) , NCI-H1568 (pulmonary) ( 10 ) , NCI-H157 (pulmonary) ( 10 ) , NCI-H1648 (pulmonary) ( 10 ) , NCI-H1666 (pulmonary) ( 10 ) , NCI-H2172 (pulmonary) ( 10 ) , NCI-H322 (pulmonary) ( 10 ) , NCI-H520 (squamous) ( 10 ) , NCI-H647 (pulmonary) ( 10 ) , ovary ( 6 ) , PANC-1 (pancreatic) ( 3 ) , PC9 (pulmonary) ( 10 ) , stomach ( 1 )

Upstream Regulation
Regulatory protein:
galectin-3 (human) ( 1 )
Putative in vivo kinases:
PKCA (human) ( 1 , 2 , 3 ) , PKCD (human) ( 3 )
Treatments:
4alphaPMA ( 1 ) , bisindolylmaleimide ( 3 ) , CID755673 ( 3 ) , Go_6976 ( 2 , 3 ) , Go_6983 ( 1 , 3 ) , hispidin ( 3 ) , LY294002 ( 3 ) , PD98059 ( 3 ) , phorbol_ester ( 2 , 3 ) , SB203580 ( 3 ) , siRNA ( 2 , 3 ) , SP600125 ( 3 )

Downstream Regulation
Effects of modification on TACSTD2:
intracellular localization ( 1 , 3 ) , molecular association, regulation ( 3 ) , phosphorylation ( 1 , 2 ) , protein degradation ( 3 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 , 2 ) , cell growth, induced ( 2 ) , cell motility, induced ( 1 , 3 ) , cytoskeletal reorganization ( 2 ) , signaling pathway regulation ( 1 ) , transcription, altered ( 1 )
Inhibit interaction with:
Claudin-7 (human) ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
gastric cancer ( 1 )

References 

1

Iwamoto S, et al. (2023) Trophoblast cell surface antigen-2 (Trop-2) phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin. J Biol Chem, 104971
37380081   Curated Info

2

Guerra E, et al. (2022) Trop-2, Na/K ATPase, CD9, PKCα, cofilin assemble a membrane signaling super-complex that drives colorectal cancer growth and invasion. Oncogene
35132180   Curated Info

3

Mori Y, et al. (2019) Trophoblast cell surface antigen 2 (Trop-2) phosphorylation by protein kinase C α/δ (PKCα/δ) enhances cell motility. J Biol Chem
31177095   Curated Info

4

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

5

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

6

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

7

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

8

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

9

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

10

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

11

Olsen JV, et al. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127, 635-48
17081983   Curated Info

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