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Site Information |
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PCSsVPSsPSFCAPS SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 5403102 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
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Upstream Regulation | |
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Downstream Regulation | |
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Effects of modification on MAFA: | |
Effects of modification on biological processes: | |
Induce interaction with: |
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Relevant diseases: |
References | |
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Walker EM, et al. (2021) Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males. Cell Rep 37, 109813
34644565 Curated Info |
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Iwaoka R, Kataoka K (2018) Glucose regulates MafA transcription factor abundance and insulin gene expression by inhibiting AMP-activated protein kinase in pancreatic β-cells. J Biol Chem
29348175 Curated Info |
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Kanai K, et al. (2011) Proteasome activator PA28{gamma} stimulates degradation of GSK3-phosphorylated insulin transcription activator MAFA. J Mol Endocrinol 47, 119-27
21646385 Curated Info |
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Guo S, Vanderford NL, Stein R (2010) Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding. J Biol Chem 285, 12655-61
20208071 Curated Info |
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Guo S, et al. (2009) The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. J Biol Chem 284, 759-65
19004825 Curated Info |