Thr360
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Home > Phosphorylation Site Page: > Thr360  -  ADRB2 (human)

Site Information
GyssNGNtGEQsGYH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 5403100

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 3 ) , COS7 (fibroblast) ( 2 )

Upstream Regulation
Regulatory protein:
G-alpha(s) (human) ( 1 )
Putative in vivo kinases:
GRK2 (human) ( 1 ) , GRK3 (human) ( 1 ) , GRK5 (human) ( 1 ) , GRK6 (human) ( 1 )
Treatments:
isoproterenol ( 1 , 3 )

Downstream Regulation
Effects of modification on ADRB2:
molecular association, regulation ( 3 ) , receptor internalization, altered ( 3 )
Induce interaction with:
ARRB2 (human) ( 3 )

References 

1

Burghi V, et al. (2023) Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor. J Biol Chem 299, 105293
37774973   Curated Info

2

Gimenez LE, et al. (2012) Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors. J Biol Chem 287, 9028-40
22275358   Curated Info

3

Krasel C, et al. (2008) Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization. J Biol Chem 283, 31840-8
18801735   Curated Info

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