Tyr319
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Home > Phosphorylation Site Page: > Tyr319  -  AT1 (human)

Site Information
YFLQLLKyIPPKAKS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448745

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , COS (fibroblast) ( 1 ) , VSMC-aorta ( 2 )

Upstream Regulation
Kinases, in vitro:
Src (human) ( 2 )
Treatments:
angiotensin ( 2 ) , PP1 ( 2 ) , vanadate ( 2 )

Downstream Regulation
Effects of modification on AT1:
molecular association, regulation ( 2 )
Induce interaction with:
PLCG1 (human) ( 2 )

References 

1

Shah BH, et al. (2004) Differential pathways of angiotensin II-induced extracellularly regulated kinase 1/2 phosphorylation in specific cell types: role of heparin-binding epidermal growth factor. Mol Endocrinol 18, 2035-48
15143154   Curated Info

2

Venema RC, et al. (1998) Angiotensin II-induced association of phospholipase Cgamma1 with the G-protein-coupled AT1 receptor. J Biol Chem 273, 7703-8
9516477   Curated Info