Tyr336
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Home > Phosphorylation Site Page: > Tyr336  -  MOR-1 (mouse)

Site Information
SCLNPVLyAFLDENF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 5397200

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, midbrain' ( 1 ) , 293 (epithelial) ( 2 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 2 ) , Src iso1 (mouse) ( 1 )
Treatments:
morphine ( 2 ) , naloxone ( 2 ) , PP2 ( 2 ) , saracatinib ( 1 )

Downstream Regulation
Effects of modification on MOR-1:
activity, induced ( 2 )
Effects of modification on biological processes:
signaling pathway regulation ( 2 )

References 

1

Zhang L, et al. (2017) Src-dependent phosphorylation of μ-opioid receptor at Tyr(336) modulates opiate withdrawal. EMBO Mol Med 9, 1521-1536
28818835   Curated Info

2

Zhang L, Loh HH, Law PY (2013) A Novel Noncanonical Signaling Pathway for the μ-Opioid Receptor. Mol Pharmacol 84, 844-53
24061856   Curated Info