Ser600

Site Information
PARQRIRsCVsAENF SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448726

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:	colorectal cancer ( 3 ) , colorectal carcinoma ( 3 ) , pancreatic cancer ( 3 ) , pancreatic carcinoma ( 3 )
Relevant cell line - cell type - tissue:	DLD1 (intestinal) ( 2 , 3 ) , HCT116 (intestinal) ( 2 ) , PANC-1 (pancreatic) ( 3 ) , SW480 (intestinal) ( 2 , 3 ) , WI-38 (fibroblast) ( 1 )

Downstream Regulation
Effects of modification on NuaK1:	activity, induced ( 3 , 4 )
Effects of modification on biological processes:	cell motility, altered ( 3 )

References
1	Humbert N, et al. (2010) Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J 29, 376-86 19927127 Curated Info
2	Suzuki A, Ogura T, Esumi H (2006) NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. J Biol Chem 281, 13915-21 16488889 Curated Info
3	Suzuki A, et al. (2004) ARK5 is a tumor invasion-associated factor downstream of Akt signaling. Mol Cell Biol 24, 3526-35 15060171 Curated Info
4	Suzuki A, et al. (2003) Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. J Biol Chem 278, 48-53 12409306 Curated Info