Tyr169
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Home > Phosphorylation Site Page: > Tyr169  -  P130Cas (mouse)

Site Information
PSPATDLyQVPPGPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448722

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
B16 (melanocyte) ( 1 ) , MEF (fibroblast) [P130Cas (mouse), homozygous knockout] ( 2 )

Upstream Regulation
Regulatory protein:
RHOC (mouse) ( 1 )
Treatments:
vanadate ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, altered ( 2 )

References 

1

Arpaia E, et al. (2012) The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene 31, 884-96
21765460   Curated Info

2

Donato DM, et al. (2010) Dynamics and mechanism of p130Cas localization to focal adhesions. J Biol Chem 285, 20769-79
20430882   Curated Info

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