Ser884
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Home > Phosphorylation Site Page: > Ser884  -  NCOA6 (human)

Site Information
NKDVTLTsPLLVNLL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 470103

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
ERK2 (human) ( 3 )

Downstream Regulation
Effects of modification on NCOA6:
molecular association, regulation ( 3 )
Effects of modification on biological processes:
transcription, altered ( 3 )
Induce interaction with:
ER-beta (human) ( 3 )
Inhibit interaction with:
ER-alpha (human) ( 3 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Chen RQ, et al. (2009) CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 69, 2663-8
19276368   Curated Info

3

Ko L, et al. (2002) Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol Endocrinol 16, 128-40
11773444   Curated Info