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Site Information |
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EPKsPGEyVNIEFGS SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 447556 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Putative in vivo kinases: | |
Kinases, in vitro: | |
Phosphatases, in vitro: | |
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Downstream Regulation | |
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Effects of modification on IRS1: | |
Effects of modification on biological processes: | |
Induce interaction with: |
References | |
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Song S, et al. (2021) Mechanism of Electroacupuncture Regulating IRS-1 Phosphorylation in Skeletal Muscle to Improve Insulin Sensitivity. Evid Based Complement Alternat Med 2021, 8631475
33824679 Curated Info |
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Hers I, et al. (2002) Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. Biochem J 368, 875-84
12220227 Curated Info |
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Sun XJ, et al. (1996) The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J Biol Chem 271, 10583-7
8631859 Curated Info |
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Rocchi S, Tartare-Deckert S, Mothe I, Van Obberghen E (1995) Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase. Endocrinology 136, 5291-7
7588273 Curated Info |
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Myers MG, et al. (1994) Role of IRS-1-GRB-2 complexes in insulin signaling. Mol Cell Biol 14, 3577-87
8196603 Curated Info |
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Sun XJ, et al. (1993) Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 13, 7418-28
7504175 Curated Info |