Thr691
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Home > Phosphorylation Site Page: > Thr691  -  FANCD2 (human)

Site Information
yGLEEYDtQDGIAIN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 470035

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 4 )
Relevant cell line - cell type - tissue:
FA-D2 (fibroblast) ( 4 ) , HeLa (cervical) ( 1 , 2 , 3 , 4 )

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 4 ) , ATR (human) ( 4 )
Kinases, in vitro:
ATR (human) ( 4 )
Treatments:
hydroxyurea ( 4 ) , ionizing_radiation ( 4 ) , UV ( 4 )

Downstream Regulation
Effects of modification on FANCD2:
activity, induced ( 4 )
Effects of modification on biological processes:
cell cycle regulation ( 4 )

References 

1

Zhou J (2008) CST Curation Set: 4842; Year: 2008; Biosample/Treatment: cell line, HeLa/UV; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate Motif (pS/pTQG) Antibody Cat#: 5074, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQG) Immunoaffinity Beads Cat#: 1993
Curated Info

2

Zhou J (2008) CST Curation Set: 4778; Year: 2008; Biosample/Treatment: cell line, HeLa/UV; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate Motif (pS/pTQG) Antibody Cat#: 5074, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQG) Immunoaffinity Beads Cat#: 1993
Curated Info

3

Ruse CI, et al. (2008) Motif-specific sampling of phosphoproteomes. J Proteome Res 7, 2140-50
18452278   Curated Info

4

Ho GP, Margossian S, Taniguchi T, D'Andrea AD (2006) Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol 26, 7005-15
16943440   Curated Info