Thr138
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Home > Phosphorylation Site Page: > Thr138  -  CDC25C (frog)

Site Information
LPRLLCStPSFKKTS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449911

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 2 ) , CDK2 (human) ( 1 )
Putative upstream phosphatases:
PPP2CA (human) ( 1 )
Phosphatases, in vitro:
PPP2CA (human) ( 1 )
Treatments:
okadaic_acid ( 1 )

References 

1

Margolis SS, et al. (2006) Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell 127, 759-73
17110335   Curated Info

2

Izumi T, Maller JL (1993) Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol Biol Cell 4, 1337-50
7513216   Curated Info