Ser1181
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Home > Phosphorylation Site Page: > Ser1181  -  eNOS (cow)

Site Information
RIRtQsFsLQERHLR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467802

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
BAEC (endothelial) ( 1 , 2 )

Upstream Regulation
Regulatory protein:
IRS1 (rat) ( 2 )
Treatments:
insulin ( 2 ) , phorbol_ester ( 2 ) , VEGF ( 1 )

Downstream Regulation
Effects of modification on eNOS:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
HSP90A (human) ( 1 )

References 

1

Chen Y, et al. (2017) Differential effects of heat shock protein 90 and serine 1179 phosphorylation on endothelial nitric oxide synthase activity and on its cofactors. PLoS One 12, e0179978
28654706   Curated Info

2

Maeno Y, et al. (2012) Inhibition of Insulin Signaling in Endothelial Cells by Protein Kinase C-induced Phosphorylation of p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K). J Biol Chem 287, 4518-30
22158866   Curated Info