Ser157
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Home > Phosphorylation Site Page: > Ser157  -  Telethonin (mouse)

Site Information
GPLRRtLsRsMsQEA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448693

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 5 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
heart ( 2 , 3 , 4 ) , myocyte-heart ( 1 )

Upstream Regulation
Kinases, in vitro:
Titin (human) ( 5 )
Treatments:
isoproterenol ( 1 )

Downstream Regulation
Effects of modification on Telethonin:
protein stabilization ( 1 ) , ubiquitination ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
hypertrophic cardiomyopathy ( 1 )

References 

1

Lewis HR, Eminaga S, Gautel M, Avkiran M (2021) Phosphorylation at Serines 157 and 161 Is Necessary for Preserving Cardiac Expression Level and Functions of Sarcomeric Z-Disc Protein Telethonin. Front Physiol 12, 732020
34566695   Curated Info

2

Possemato A (2008) CST Curation Set: 3846; Year: 2008; Biosample/Treatment: tissue, heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

3

Possemato A (2007) CST Curation Set: 3394; Year: 2007; Biosample/Treatment: tissue, heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

4

Guo A (2007) CST Curation Set: 2922; Year: 2007; Biosample/Treatment: tissue, heart/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

5

Mayans O, et al. (1998) Structural basis for activation of the titin kinase domain during myofibrillogenesis. Nature 395, 863-9
9804419   Curated Info

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