Ser199
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Home > Phosphorylation Site Page: > Ser199  -  IGFBP1 (human)

Site Information
ETsGEEIsKFYLPNC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 51637400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 , 4 , 5 ) , multiple reaction monitoring (MRM) ( 3 ) , phospho-antibody ( 4 , 5 ) , western blotting ( 4 , 5 )
Disease tissue studied:
endometrial cancer ( 3 ) , liver cancer ( 1 , 5 )
Relevant cell line - cell type - tissue:
endometrial stromal ( 2 , 3 ) , HepG2 (hepatic) ( 1 , 5 ) , stromal ( 4 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 2 )
Treatments:
conditioned medium ( 1 ) , hypoxia ( 2 , 3 ) , leucine_deprivation ( 4 ) , rapamycin ( 3 )

Downstream Regulation
Effects of modification on IGFBP1:
activity, inhibited ( 3 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
signaling pathway regulation ( 3 )
Induce interaction with:
CK2B (human) ( 3 )

References 

1

Rosario FJ, et al. (2023) Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability. Int J Mol Sci 24
37108437   Curated Info

2

Gupta MB, et al. (2022) Increased Colocalization and Interaction Between Decidual Protein Kinase A and Insulin-like Growth Factor-Binding Protein-1 in Intrauterine Growth Restriction. J Histochem Cytochem 70, 515-530
35801847   Curated Info

3

Abu Shehab M, et al. (2020) Inhibition of decidual IGF-1 signaling in response to hypoxia and leucine deprivation is mediated by mTOR and AAR pathways and increased IGFBP-1 phosphorylation. Mol Cell Endocrinol 512, 110865
32502935   Curated Info

4

Shehab MA, et al. (2017) Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity. Mol Cell Endocrinol 452, 1-14
28435049   Curated Info

5

Damerill I, et al. (2016) Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition. Mol Endocrinol 30, 201-16
26714229   Curated Info