Ser7
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Home > Phosphorylation Site Page: > Ser7  -  NUMB iso3 (human)

Site Information
_MNKLRQsFRRKKDV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 487518

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKCZ (human) ( 1 )

Downstream Regulation
Effects of modification on NUMB iso3:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
endocytosis, inhibited ( 1 )
Inhibit interaction with:
AP2A1 (human) ( 1 ) , CDH1 (human) ( 1 ) , CTNND1 (human) ( 1 )

References 

1

Sato K, et al. (2011) Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell 22, 3103-3119
21775625   Curated Info