Tyr139
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Home > Phosphorylation Site Page: > Tyr139  -  CCR2 (human)

Site Information
ILLTIDRyLAIVHAV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448635

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , Mono Mac 1 (myeloid) ( 1 )

Upstream Regulation
Putative in vivo kinases:
JAK2 (human) ( 1 )
Treatments:
AG490 ( 1 ) , MCP-1 ( 1 )

Downstream Regulation
Effects of modification on CCR2:
molecular association, regulation ( 1 )
Induce interaction with:
G-alpha i2 (human) ( 1 ) , JAK2 (human) ( 1 ) , STAT3 (human) ( 1 )

References 

1

Mellado M, et al. (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J Immunol 161, 805-13
9670957   Curated Info

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