Ser641

Site Information
YRYPRPAsVPPsPSL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448237

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 5 ) , phospho-antibody ( 1 , 3 , 4 , 6 ) , western blotting ( 1 , 3 , 4 , 6 )
Relevant cell line - cell type - tissue:	'muscle, skeletal' ( 4 , 6 ) , GH3 (epithelial) ( 3 ) , heart ( 5 ) , L6 (myoblast) ( 1 ) , muscle ( 5 )

Upstream Regulation
Regulatory protein:	GSK3B (rat) ( 3 ) , SIRT1 (rat) ( 3 ) , TSC2 (rat) ( 3 )
Treatments:	cisplatin ( 1 ) , fasting ( 6 ) , fluorouracil ( 1 ) , insulin ( 4 , 6 ) , leucovorin ( 1 ) , muscle contraction ( 4 , 6 ) , refeeding ( 6 ) , resveratrol ( 3 ) , SB415286 ( 3 )

References
1	Mora S, Adegoke OAJ (2021) The effect of a chemotherapy drug cocktail on myotube morphology, myofibrillar protein abundance, and substrate availability. Physiol Rep 9, e14927 34197700 Curated Info
2	Pérez-Mendoza M, Rivera-Zavala JB, Díaz-Muñoz M (2014) Daytime restricted feeding modifies the daily variations of liver gluconeogenesis: adaptations in biochemical and endocrine regulators. Chronobiol Int 31, 815-28 24766192 Curated Info
3	Monteserin-Garcia J, et al. (2013) Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis. FASEB J 27, 1561-71 23292070 Curated Info
4	Lin FC, et al. (2012) Effect of insulin and contraction on glycogen synthase phosphorylation and kinetic properties in epitrochlearis muscles from lean and obese Zucker rats. Am J Physiol Cell Physiol 302, C1539-47 22403789 Curated Info
5	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
6	Lai YC, Zarrinpashneh E, Jensen J (2010) Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents. J Appl Physiol 108, 1106-15 20185632 Curated Info