Thr252
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Home > Phosphorylation Site Page: > Thr252  -  p70S6K (rat)

Site Information
HDGTVTHtFCGTIEY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448606

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 1 ) , [32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 2 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 3 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 2 ) , PC CL 3 (thyroid cell) ( 1 )

Upstream Regulation
Treatments:
insulin ( 1 , 2 ) , rapamycin ( 1 , 2 ) , serum ( 2 ) , TSH ( 1 ) , wortmannin ( 2 , 3 )

Downstream Regulation
Effects of modification on p70S6K:
enzymatic activity, induced ( 2 , 3 )

References 

1

Blancquaert S, et al. (2010) cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. Mol Endocrinol 24, 1453-68
20484410   Curated Info

2

Weng QP, et al. (1998) Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J Biol Chem 273, 16621-9
9632736   Curated Info

3

Weng QP, et al. (1995) Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc Natl Acad Sci U S A 92, 5744-8
7777579   Curated Info

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