Ser21
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Home > Phosphorylation Site Page: > Ser21  -  KIF20A (human)

Site Information
sDDDVVVsPMFESTA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4921068

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
cervical cancer ( 4 ) , cervical adenocarcinoma ( 4 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 , 2 ) , HeLa S3 (cervical) [PLK1 (human), knockdown, Tet-inducible PLK1 siRNA] ( 3 ) , HeLa S3 (cervical) ( 3 , 4 ) , SF9 ( 2 )

Upstream Regulation
Putative in vivo kinases:
CDK1 (human) ( 2 )
Treatments:
nocodazole ( 2 , 4 )

Downstream Regulation
Effects of modification on KIF20A:
intracellular localization ( 2 ) , molecular association, regulation ( 2 ) , protein conformation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )
Inhibit interaction with:
INCENP (human) ( 2 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Kitagawa M, et al. (2014) Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis. Cell Rep 7, 166-79
24656812   Curated Info

3

Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457
20860994   Curated Info

4

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

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