Ser9
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Home > Phosphorylation Site Page: > Ser9  -  p53 (mouse)

Site Information
TAMEEsQsDIsLELP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447537

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 1 ) , [32P] bio-synthetic labeling ( 1 , 4 ) , immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 2 , 4 ) , phosphopeptide mapping ( 1 , 4 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , COS (fibroblast) ( 1 , 4 ) , SV3T3 (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CK1D (human) ( 1 ) , CK1E (human) ( 1 )
Kinases, in vitro:
CK1A (human) ( 3 ) , CK1D (human) ( 1 ) , CK1E (human) ( 1 )
Treatments:
IC261 ( 1 )

References 

1

Knippschild U, et al. (1997) p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene 15, 1727-36
9349507   Curated Info

2

Hao M, et al. (1996) Mutation of phosphoserine 389 affects p53 function in vivo. J Biol Chem 271, 29380-5
8910602   Curated Info

3

Milne DM, Palmer RH, Campbell DG, Meek DW (1992) Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme. Oncogene 7, 1361-9
1620549   Curated Info

4

Wang Y, Eckhart W (1992) Phosphorylation sites in the amino-terminal region of mouse p53. Proc Natl Acad Sci U S A 89, 4231-5
1584757   Curated Info