Thr252
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Home > Phosphorylation Site Page: > Thr252  -  BACE (human)

Site Information
YTGSLWYtPIRREWY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 48881800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal'-brain ( 1 ) , brain ( 1 ) , HEK293T (epithelial) ( 1 ) , PC-12 (chromaffin) ( 1 ) , SK-N-BE(2) (neural crest) ( 1 )

Upstream Regulation
Regulatory protein:
CDK5R1 (human) ( 1 )
Putative in vivo kinases:
CDK5 (human) ( 1 )
Kinases, in vitro:
CDK5 (human) ( 1 )
Treatments:
seliciclib ( 1 )

Downstream Regulation
Effects of modification on BACE:
activity, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 )

References 

1

Song WJ, et al. (2015) Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease. PLoS One 10, e0136950
26317805   Curated Info