Thr219
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Home > Phosphorylation Site Page: > Thr219  -  NDEL1 (mouse)

Site Information
ASLsLPAtPVGKGTE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 468252

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 3 , 4 , 5 , 6 , 7 , 8 , 9 , 11 , 12 ) , mutation of modification site ( 2 , 10 ) , phospho-antibody ( 1 , 2 , 10 ) , western blotting ( 1 , 2 , 10 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 4 ) , 'brain, embryonic' ( 6 ) , 'fat, brown' ( 9 ) , 3T3 (fibroblast) ( 10 ) , brain ( 5 , 7 , 9 ) , COS (fibroblast) ( 10 ) , heart ( 9 ) , kidney ( 9 ) , liver ( 3 , 8 , 11 ) , lung ( 9 ) , MEF (fibroblast) [IGF1R (mouse)] ( 12 ) , spinal cord ( 1 ) , spleen ( 9 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (mouse) ( 10 ) , ERK2 (mouse) ( 10 )
Kinases, in vitro:
CDK5 (human) ( 2 , 12 )
Treatments:
insulin ( 4 ) , U0126 ( 10 ) , wounding ( 10 )

Downstream Regulation
Effects of modification on NDEL1:
activity, induced ( 10 ) , intracellular localization ( 10 )
Effects of modification on biological processes:
cell motility, altered ( 10 ) , cytoskeletal reorganization ( 2 )

References 

1

Klinman E, Holzbaur EL (2015) Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein. Cell Rep 12, 462-73
26166569   Curated Info

2

Okamoto M, et al. (2015) DBZ Regulates Cortical Cell Positioning and Neurite Development by Sustaining the Anterograde Transport of Lis1 and DISC1 through Control of Ndel1 Dual-Phosphorylation. J Neurosci 35, 2942-58
25698733   Curated Info

3

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

6

Guo A (2011) CST Curation Set: 12476; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

7

Guo A (2011) CST Curation Set: 12477; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

8

Guo A (2011) CST Curation Set: 12478; Year: 2011; Biosample/Treatment: tissue, liver/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

9

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

10

Shen Y, et al. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell 14, 342-53
18331715   Curated Info

11

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info

12

Mori D, et al. (2007) NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol 27, 352-67
17060449   Curated Info

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