Tyr1208

Site Information
EyVNEPLyLNTFANT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4825109

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 1 )

Downstream Regulation
Effects of modification on HER4:	molecular association, regulation ( 3 )
Induce interaction with:	GRB2 (human) ( 3 )

References
1	Moritz A (2010) CST Curation Set: 9059; Year: 2010; Biosample/Treatment: cell line, HeLa/Peroxide; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	Kaushansky A, et al. (2008) System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol 15, 808-17 18721752 Curated Info
3	Schulze WX, Deng L, Mann M (2005) Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol 1, 2005.0008 16729043 Curated Info