Ser351
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser351  -  Nur77 (human)

Site Information
GRRGRLPsKPKQPPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447942

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 4 , 5 , 6 ) , mutation of modification site ( 2 , 7 ) , phospho-antibody ( 3 , 8 ) , western blotting ( 2 , 3 )
Disease tissue studied:
lung cancer ( 7 ) , non-small cell lung cancer ( 7 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 8 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 8 ) , HeLa (cervical) ( 1 , 5 , 6 ) , HUVEC (endothelial) ( 2 ) , NCI-H460 (pulmonary) ( 7 )

Upstream Regulation
Regulatory protein:
TGFBR3 (human) ( 3 )
Putative in vivo kinases:
Akt1 (mouse) ( 7 , 8 )
Kinases, in vitro:
Akt1 (human) ( 8 )
Treatments:
PDGF ( 8 ) , TGF-beta ( 3 ) , wortmannin ( 8 )

Downstream Regulation
Effects of modification on Nur77:
activity, inhibited ( 8 ) , phosphorylation ( 7 )
Effects of modification on biological processes:
apoptosis, induced ( 7 ) , cell growth, induced ( 2 ) , cell motility, induced ( 2 ) , cytoskeletal reorganization ( 2 , 7 ) , transcription, inhibited ( 8 )

References 

1

Huang H, et al. (2016) Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography. Mol Cell Proteomics 15, 3282-3296
27281782   Curated Info

2

Li Y, et al. (2015) Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis. Oncotarget 6, 24261-76
26155943   Curated Info

3

Palumbo-Zerr K, et al. (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat Med 21, 150-8
25581517   Curated Info

4

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
22322096   Curated Info

5

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

6

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

7

Han YH, et al. (2006) Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene 25, 2974-86
16434970   Curated Info

8

Pekarsky Y, et al. (2001) Akt phosphorylates and regulates the orphan nuclear receptor Nur77. Proc Natl Acad Sci U S A 98, 3690-4
11274386   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.